‘Junk’ DNA meets the p53 network
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‘Junk' DNA meets the p53 network
A major part of the genome of higher eukaryotes consists of non-coding sequences. In former times, these sequences were called ‘junk-DNA’ as no specific function could be attributed to them. More recent research has shown that small non-coding RNAs are contained in these parts of the genome. These noncoding RNAs have a fundamental role in gene regulation. Regulation of gene expression in eukary...
متن کاملThe role of Junk DNA
Many efforts have been done in order to explain the role of junk DNA, but its function remain to be elucidated. In addition the GC-content variations among species still represent an enigma. Both these two mysteries can have a common explanation: we hypothesize that the role of junk DNA is to preserve the mutations probability that is intrinsically reduced in GC-poorest genomes.
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With the advent of deep sequencing technologies and the ability to analyze whole genome sequences and transcriptomes, there has been a growing interest in exploring putative functions of the very large fraction of the genome that is commonly referred to as ‘‘junk DNA.’’ Whereas this is an issue of considerable importance in genome biology, there is an unfortunate tendency for researchers and sc...
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Eukaryote and also human DNA contains large portion of noncoding sequences. As for the coding DNA, the noncoding DNA may be unique or in more identical or similar copies. DNA sequences with high copy numbers are then called repetitive sequences. If the copies of a sequence motif lie adjacent to each other in a block, or an array, we are speaking about tandem repeats, the repetitive sequences di...
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sciencemag.org SCIENCE Paleoindian, and fishtail points previously provided a roadmap that archaeologists used to trace the spread of Paleoindians throughout the Americas. Such a roadmap is lacking for pre-Clovis sites. Assemblages with distinctive stemmed (“tanged”) chipped-stone projectile points, crescents (lunate-shaped), and leaf-shaped bifaces found in Japan, northeast Asia, western North...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2008
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb.2008.68